Y-27632 dihydrochloride

General description

Product name

Y-27632 dihydrochloride, Rho kinase inhibitor

Description

Selective Rho kinase inhibitor

Biological description

Y-27632 is a research tool with a wide variety of biological effects, mainly used in the field of stem cell research for their maintenance and differentiation. It is commonly used as a 3D growth matrix component; it is also a component of the differentiation media of brain organoids.

How others have used Y-27632 in their research:

IPSC tissue culture maintenance; Y-27632 10 µM for 24 h; Montefiori et al (2018)
Reprogramming of breast cancer cells to induce progenitor-like cells (iPL); 2 µM Y27632; Yuan and Others (2018)
Differentiation: Y-27632 allows human embryonic stem cells to survive and differentiate into cortical and basal telencephalic progenitors; Watanabe et al (2007)

Purity: > 99%

CAS number: 129830-38-2

Properties

Chemical name

(R) – (+) – trans-4- (1-aminoethyl) -N- (4-pyridyl) cyclohexanecarboxamide dihydrochloride

Molecular weight: 320.26

Molecular formula: C14H21N3O.2HCl

PubChem identifier: 9901617

Storage instructions

Store at + 4 ° C. Store under dry conditions. The product can be stored for up to 12 months.

Solubility Summary

Soluble in water up to 100 mM and in DMSO up to 100 mM

Driving

Whenever possible, you should prepare and use the solutions on the same day. However, if you need to prepare stock solutions in advance, we recommend that you store the solution in aliquots in hermetically sealed vials at -20 ° C. These can generally be used for up to one month. Before use and before opening the vial, we recommend that you allow your product to equilibrate at room temperature for at least 1 hour.

Smiles

Cl.Cl.O = C (Nc1ccncc1) [C @@ H] 2CC [C @ H] (CC2) [C @@ H] (C) N

Fountain: Synthetic

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